Principles and Applications of Optical Coherence Tomography

Level: Advanced Length: 4 hours Format: In-Person Lecture Intended Audience: This material is appropriate for scientists, engineers, and clinicians who are performing research in medical imaging. Description: Optical coherence tomography (OCT) is an emerging imaging modality, which is the optical analog of ultrasound. OCT can perform high resolution, cross sectional and volumetric imaging of the internal structure of biological tissues and materials. OCT is promising for biomedical research because it enables tissue pathology to be imaged in situ and in real time. Dramatic advances in imaging resolution and speed have been achieved using spectral domain OCT (SD-OCT) and swept source OCT (SS-OCT). Functional extensions such as OCT angiography (OCTA) enable three dimensional microvasculature to be imaged using motion contrast from flowing blood cells. OCT technology also has numerous applications in fields spanning clinical medicine, fundamental research and nondestructive evaluation of materials. This course describes OCT principles including interferometry, Fourier domain detection, spectral domain and swept source OCT, and OCT angiography. The course also discussed translation to clinical medicine using example applications. Learning Outcomes: This course will enable you to: - describe OCT imaging devices such as microscopes, hand held probes and catheters - explain the key aspect of clinical imaging in ophthalmology, gastroenterology, and cardiology - explain a systems viewpoint of OCT technology - describe the principles of optical coherence tomography (OCT) - describe laser light source technology for OCT - explain factors governing translating technology from the laboratory to the clinic - describe OCT detection approaches and factors governing performance - describe functional imaging such as Doppler OCT and OCT angiography Instructor(s): James G. Fujimoto is Elihu Thomson Professor of Electrical Engineering at MIT, visiting professor of ophthalmology at Tufts University School of Medicine, and adjunct professor at the Medical University of Vienna. His group and collaborators were responsible for the invention and development of optical coherence tomography (OCT), performing some of the first studies in ophthalmology. He was a cofounder of the startup company Advanced Ophthalmic Devices, which developed ophthalmic OCT and was acquired by Carl Zeiss and LightLab Imaging, which developed cardiovascular OCT and was acquired by Goodman, Ltd. Dr. Fujimoto published over 500 peer-reviewed journal articles and coedited 13 books. Dr. Fujimoto has honorary doctorates from the Nicolaus Copernicus University in Poland and the Friedrich Alexander University of Erlangen-Nuremberg and is a member of the National Academy of Engineering, National Academy of Sciences, and American Academy of Arts and Sciences. Event: SPIE Photonics West 2025 Course Held: 26 January 2025